(E) Manifestation of Mac-1, as determined by circulation cytometry, in the BM-derived tumor cells (M/E p53WT and p53null, MFI, .0001; n = 5). suggests that dysregulated Pol I transcription is essential for the maintenance of their leukemia-initiating potential. Collectively, these findings demonstrate the restorative utility of this new class of … Continue reading (E) Manifestation of Mac-1, as determined by circulation cytometry, in the BM-derived tumor cells (M/E p53WT and p53null, MFI,